High production of EVs using bioreactor

The bioreactor produces approximately seven times more mesenchymal stem cell-derived EVs than static culture conditions. The mechanism underlying the increased production of EVs in a flat-plate bioreactor and its application to acute kidney injury is investigated. This study describes the mechanism of EV production by demonstrating the link between EV biogenesis and increased calcium ion concentration under flow conditions.

Reference

Extracellular vesicles generated using bioreactors and their therapeutic effect on the acute kidney injury model.“, Advanced Healthcare Materials, 2021